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Rabies are caused by viruses of the genus Lyssavirus in the family Rhabdoviridae. Although all mammals are thought to be susceptible to rabies infection, the primary hosts are carnivores and bats. Most human exposure to rabies occurs via an animal bite in which the skin is broken and the virus is transmitted from the infected animal's saliva to the blood and tissues of the victim. The rabies virus infects the human nervous system causing acute encephalomyelitis, an inflammation of the brain and spinal cord. Death, usually by respiratory failure, occurs within seven to 10 days after appearance of the first symptoms. The average incubation period before symptoms of the disease appear is three to seven weeks, with a range of 10 days to seven years.